Fantastic Four # 46 (Jan 1966). In this book and the ones before, there seems to be some issue with Crystal’s face. There’s one notable example where it looks like Lee had Romita redraw her face. Maybe Lee wanted her eyebrows higher so she would look different than Sue? on this cover, it looks like there may have been another change to Crystal’s face and to Black Bolt’s face. Not sure what’s going on with Karnak’s eyes: he looks like he’s seen a ghost. Anybody out there ever seen the original art to this cover? I never have.
Here’s some art from one of the Marvel reprints, so some loss of detail. You gotta love Lockjaw.
I really enjoy pages like this one where Jack tells you the origin of an entirely new race of beings in just a couple panels using all sorts of creative character designs and Kirby contraptions.