This re-imaging of the cover to Fantastic Four #49 is by American artist Otis Frampton. Otis is the creator of the ‘Oddly Normal‘ graphic novel series, published by Viper Comics. His other credits include sketch cards sets for Topps and online content for Star Wars.com. You can watch live recordings of Otis colouring this piece here and here.
The original cover, by Jack Kirby and Joe Sinnott, can be found here.